Genitourinary/Renal

Clinical Trial NameClinical Trial Full TitlePrincipal InvestigatorProject site statusClinical trials gov number
(Astellas) 7465-CL-0301An Open-Label, Randomized Phase 3 Study to Evaluate Enfortumab Vedotin vs Chemotherapy in Subjects with Previously Treated Locally Advanced or Metastatic Urothelial Cancer (EV-301)Hotte, Dr Sebastien Open to recruitmentNCT03474107
(AstraZeneca) D933IC00003 / BAYOUA Phase II, Randomized, Multi-Center, Double-Blind, Comparative Global Study to Determine the Efficacy and Safety of Durvalumab in Combination With Olaparib for First-Line Treatment in Cisplatin-Ineligible Patients With Unresectable Stage IV Urothelial CancerMukherjee, Dr SomOpen to recruitmentNCT03459846
(Bayer) BAY 1163877 / 17403 / FORT-1A randomized, open label, multicenter Phase 2/3 study to evaluate the efficacy and safety of
rogaratinib (BAY 1163877) compared to chemotherapy in patients with FGFR-positive
locally advanced or metastatic urothelial carcinoma who have received prior platinum containing
chemotherapy
Hotte, Dr Sebastien Open to recruitmentNCT03410693
(BMS) CA018005 / FRACTION-RCCA Phase 2, Fast Real-time Assessment of Combination Therapies in Immuno-ONcology Study in
Participants with Advanced Renal Cell Carcinoma
Hotte, Dr Sebastien Open to recruitmentNCT02996110
(BMS) CA2099KD / CheckMate 9KDA Phase 2 Study of Nivolumab in Combination with Either Rucaparib, Docetaxel, or
Enzalutamide in Men with Castration-resistant Metastatic Prostate Cancer (CheckMate 9KD:
CHECKpoint pathway and nivoluMAb clinical Trial Evaluation 9KD)
Hotte, Dr Sebastien Open to recruitmentNCT03338790
(CCTG) IND.234 / PC-BETS - Master ProtocolProstate Cancer Biomarker Enrichment and Treatment Selection (PC_BETS) Study - Master Screening ProtocolMukherjee, Dr SomOpen to recruitmentNCT03385655 (Master)
(CCTG) IND.234 / PC-BETS - Sub-Study AA Phase II Study of AZD1775, A WEE1 Inhibitor, in Patients with Metastatic Castration-Resistant Prostate Cancer - A Sub-Study of IND.234Mukherjee, Dr SomOpen to recruitmentNCT03385655 A
(CCTG) IND.234 / PC-BETS - Sub-Study BA Phase II Study of Savolitinib, A CMET Inhibitor, in Patients with Metastatic Castration-Resistant Prostate Cancer - A Sub-Study of IND.234Mukherjee, Dr SomOpen to recruitmentNCT03385655 B
(CCTG) IND.234 / PC-BETS - Sub-Study CA Phase II Study of Darolutamide (ODM-201) in Patients with Metastatic Castration-Resistant Prostate Cancer Previously Treated with Abiraterone Acetate or Enzalutamide - A Sub-Study of IND.234Mukherjee, Dr SomOpen to recruitmentNCT03385655 C
(CCTG) IND.234 / PC-BETS - Sub-Study IND.223A Phase II Study of Palbociclib, A CDK4/6 Inhibitor, in Patients With Metastatic Castration-Resistant Prostate CancerMukherjee, Dr SomOpen to recruitmentNCT02905318
(Clovis) CO-338-052 / TRITON2A Multicenter, Open-label Phase 2 Study of Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer Associated with Homologous Recombination DeficiencyHotte, Dr Sebastien Open to recruitmentNCT02952534
(JCC) Prostate HBINon-Targeted Low Dose Radiotherapy For Recurrent Prostate CancerDayes, Dr IanOpen to recruitmentNCT03196778
(JGH) PCS IX / PCS 9The Role of Stereotactic Body Radiotherapy in the Management of Castration-Resistant Prostate Cancer With Oligometastases: An Adaptive Phase II/III Randomized Trial.Tsakiridis, Dr TheosOpen to recruitmentNCT02685397
(Merck) MK-3475-564 / KEYNOTE 564A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Pembrolizumab (MK-3475) as Monotherapy in the Adjuvant Treatment of Renal Cell Carcinoma Post Nephrectomy (KEYNOTE-564)Lalani, Dr Aly-KhanOpen to recruitmentNCT03142334
(PHRI) RADICAL PC2A Randomized Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer PatientsLeong, Dr DarrylOpen to recruitmentNCT03127631
(Roche) CO39303A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER TRIAL TESTING IPATASERTIB PLUS ABIRATERONE PLUS PREDNISONE/PREDNISOLONE, RELATIVE TO PLACEBO PLUS ABIRATERONE PLUS PREDNISONE/PREDNISOLONE IN ADULT MALE PATIENTS WITH ASYMPTOMATIC OR MILDLY SYMPTOMATIC, PREVIOUSLY UNTREATED, METASTATIC CASTRATE-RESISTANT PROSTATE CANCER Mukherjee, Dr SomOpen to recruitmentNCT03072238
OCOG-2013-PETMUSEImpact of Positron Emission Tomography (PET) Imaging in Muscle-invasive Urothelial Carcinoma of the Bladder StagingMukherjee, Dr SomOpen to recruitmentNCT02462239
OCOG-2016-MISTERAssessment of New Molecular Imaging Strategies for Prostate Cancer: Predictive Value of Established and Novel PET Radiotracers in Castration-Resistant Prostate Cancer Hotte, Dr Sebastien Open to recruitmentNCT02813226
(UHN) TOPCOPTOward Personalizing Care for Older men with mCRPC - understanding and predicting treatment toxicities (the TOPCOP study)Hotte, Dr Sebastien Suspended/On holdNCT02512185
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