Hematology

Clinical Trial NameClinical Trial Full TitlePrincipal InvestigatorProject site statusClinical trials gov number
(AbbVie) M24-108A Multicenter, Phase 1b, Open-label Study to Evaluate Dose Optimization Measures and Safety of ABBV-383 in Subjects with Relapsed or Refractory Multiple MyelomaDr Hira MianOpen to recruitmentNCT05650632
(Amgen) 20190360 / Golden GatePhase 3 Randomized, Controlled Study of Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia With Safety Run-in (Golden Gate Study)Dr Michael RadfordSuspended/On holdNCT04994717
(AstraZeneca) D7230C00001A Modular Phase I/II, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, Pharmacodynamics, and Preliminary Efficacy of AZD0305 as Monotherapy or in Combination With Anticancer Agent(s) in Participants with Relapsed or Refractory Multiple MyelomaDr Hira MianOpen to recruitmentNCT06106945
(BeiGene) BGB-3111-308 / MAHOGANYA Phase 3 Randomized, Open-Label, Multicenter Study of Zanubrutinib (BGB-3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone LymphomaDr Gwynivere DaviesOpen to recruitmentNCT05100862
(CCTG) HD.11A Randomized Phase II Trial of Pembrolizumab and Brentuximab Vedotin versus GDP Followed by High Dose Chemotherapy and Autologous Stem Cell Transplantation for Relapsed/Refractory Classical Hodgkin LymphomaDr Amaris BalitskyOpen to recruitmentNCT05180097
(CCTG) LY.17A Multi-stage Randomized Phase II Study of Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell LymphomaDr Graeme FraserSuspended/On holdNCT02436707
(CCTG) MY.13A PHASE III NON-INFERIORITY RANDOMIZED CONTROLLED TRIAL OF FIXED DURATION VERSUS CONTINUOUS DARATUMUMAB AMONG TRANSPLANT INELIGIBLE OLDER ADULTS WITH NEWLY-DIAGNOSED MULTIPLE MYELOMADr Hira MianOpen to recruitmentNCT06182774
(CCTG) SC.26 / EASEEmotion and Symptom-focused Engagement (EASE): A Randomized Controlled Trial for Individuals with Acute LeukemiaDr Alejandro Garcia-HortonOpen to recruitmentNCT04224974
(EMN) EMN28 / 68284528MMY3005 / CARTITUDE-6A Phase 3 Randomized Study Comparing Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Ciltacabtagene Autoleucel versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Autologous Stem Cell Transplant (ASCT) in Participants with Newly Diagnosed Multiple Myeloma who are Transplant EligibleDr Mohammed AljamaOpen to recruitmentNCT05257083
(Janssen) 64407564MMY3009 / MonumenTAL-6A Phase 3 Randomized Study Comparing Talquetamab in Combination with Pomalidomide (Tal-P),Talquetamab in Combination with Teclistamab (Tal-Tec), and Investigator’s Choice of EitherElotuzumab, Pomalidomide, and Dexamethasone (EPd) or Pomalidomide, Bortezomib, andDexamethasone (PVd) in Participants with Relapsed or Refractory Myeloma who Have Received 1 to4 Prior Lines of Therapy Including an Anti-CD38 Antibody and LenalidomideDr Hira MianSuspended/On holdNCT06208150
(Pfizer) C1071007 / MAGNETISMM-7A RANDOMIZED, 2-ARM, PHASE 3 STUDY OF ELRANATAMAB (PF-06863135) VERSUS LENALIDOMIDE IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA WHO ARE MINIMAL RESIDUAL DISEASE POSITIVE AFTER UNDERGOING AUTOLOGOUS STEM-CELL TRANSPLANTATIONDr Mohammed AljamaOpen to recruitmentNCT05317416
Download PDF