Hematology

Clinical Trial NameClinical Trial Full TitlePrincipal InvestigatorProject site statusClinical trials gov number
(Astex) SGI-110-07 / ASTRAL 3A Phase 3, Multicenter, Randomized, Open-Label Study of Guadecitabine (SGI-110) versus Treatment Choice in Adults with Myelodysplastic Syndromes (MDS) or Chronic Myelomonocytic Leukemia (CMML) Previously Treated with Hypomethylating AgentsLeber, Dr BrianOpenNCT02907359
(Janssen) 54179060CLL3011 / GLOWA Randomized, Open-label Phase 3 study of the Combination of Ibrutinib plus Venetoclax
versus Chlorambucil plus Obinutuzumab for the First-line Treatment of Subjects with Chronic
Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Fraser, Dr GraemeOpenNCT03462719
(Novartis) CINC424C2301 / REACH 2A phase III randomized open-label multi-center study of ruxolitinib versus best available therapy in patients with corticosteroid-refractory acute graft vs. host disease after allogeneic stem cell transplantationLeber, Dr BrianOpenNCT02953678
(Novartis) CINC424D2301 / REACH 3A Phase III Randomized Open-label Multi-center Study of Ruxolitinib vs. Best Available Therapy in Patients With Corticosteroid-refractory Chronic Graft vs Host Disease After Allogeneic Stem Cell Transplantation (REACH 3)Foley, Dr RonanOpenNCT03112603
MCRN 004A Randomized Phase II, Open Label, Study of Daratumumab, Weekly Low-Dose Oral Dexamethasone and Cyclophosphamide with or without Pomalidomide in Patients with Relapsed and Refractory Multiple Myeloma.Kouroukis, Dr TomOpenNCT03215524
(CCTG) LY.17A MULTI-STAGE RANDOMIZED PHASE II STUDY OF NOVEL COMBINATION THERAPY IN THE TREATMENT OF RELAPSED AND REFRACTORY AGGRESSIVE B-CELL LYMPHOMAFraser, Dr GraemeOn holdNCT02436707
(Celgene) AZA-MDS-003A phase 3, multicentre, randomized, double-blind study to compare with efficacy and safety of oral azacitidine plus best supportive care versus placebo plus best supportive care in subjects with red blood cell transfusion-dependent anemia and thrombocytopenia due to IPSS lower-risk myelodysplatic syndromesLeber, Dr BrianOn holdNCT01566695
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